Publications

Risk of SARS-CoV-2 Infection and Hospitalisation in Immunocompromised Children: A Population-Based Cohort Study in Italy and Norway

Chiara CD, Boracchini R, Trinh NTH, Giugni A, Sturniolo G, Visonà E, Judd A, Prevost ML, Thorne C, Hardelid P, Giaquinto C, Lupattelli A, Donà D, Cantarutti A

Acta Paediatr. 2026 Mar 23. doi: 10.1111/apa.70509.
PMID: 41869987

Wheeze Among Children Born During COVID-19 Lockdown

Barbieri E, Cantarutti A, Boracchini R, Bonadies L, Donà D, Giaquinto C, Baraldi E

JAMA Netw Open. 2024 Jul 1;7(7):e2420792. doi: 10.1001/jamanetworkopen.2024.20792
PMID: 38980679

Validation of Administrative Data and Timing of Point Prevalence Surveys for Antibiotic Monitoring

Boracchini R, Brigadoi G, Barbieri E, Liberati C, Rossin S, Tesser F, Chiusaroli L, Demarin GC, Maestri L, Tirelli F, Giaquinto C, Da Dalt L, Bressan S, Cantarutti A, Donà D

JAMA Netw Open. 2024 Sep 3;7(9):e2435127. doi: 10.1001/jamanetworkopen.2024.35127
PMID: 39316397

RSV Detection and Antibiotic Prescribing Decisions for Pediatric Respiratory Tract Infections

Boracchini R, Brigadoi G, Salvadori S, Padoan A, Plebani M, Giaquinto C, Bertizzolo L, Borchiellini M, Parisi S, Hagemann C, Donà D, Cantarutti A; Pedianet Network Group

JAMA Netw Open. 2026 Mar 2;9(3):e260409. doi: 10.1001/jamanetworkopen.2026.0409.
PMID: 41774441

Recurrent wheezing as a mediator between early-life exposures and childhood asthma: a mediation analysis in an Italian primary care paediatric cohort

Boracchini R, Canova C, Bendoni S, Di Chiara C, Giaquinto C, Baraldi E, Cantarutti A

BMJ Public Health. 2026 Feb 11;4(1):e003442. doi: 10.1136/bmjph-2025-003442.
PMID: 41710083

Changes in pediatric primary care contacts: has the RSV-immunization modified the age-related access?

Boracchini R, Barbieri E, Canova B, Baraldi E, Giaquinto C, Cantarutti A

Ital J Pediatr. 2026 Feb 2;52(1):32. doi: 10.1186/s13052-026-02205-w.
PMID: 41629983

Trajectories of antibiotic prescriptions in Italian children in the first four years of life: a retrospective birth-cohort study

Rosato I, Porcu G, Donà D, Batzella E, Giaquinto C, Cantarutti A, Canova C

BMC Public Health. 2026 Jan 26;26(1):311. doi: 10.1186/s12889-025-25657-x.
PMID: 41588382

Sociodemographic and socioeconomic disparities in pediatric influenza vaccination: A cohort study from the pedianet network

Vera R, Isabella R, Di Chiara C, Anna C, Cristina C

Vaccine. 2025 Aug 30;62:127494. doi: 10.1016/j.vaccine.2025.127494.
PMID: 40652686

Impact of Prior SARS-CoV-2 Infection on COVID-19 Vaccine Effectiveness in Children and Adolescents in Norway and Italy

Barbieri E, Trinh NTH, Di Chiara C, Corrao G, Boracchini R, Rosa E, Liberati C, Donà D, Lupattelli A, Giaquinto C, Cantarutti A

Vaccines (Basel). 2025 Jun 27;13(7):698. doi: 10.3390/vaccines13070698.
PMID: 40733675

Real-world effectiveness of influenza vaccination in preventing influenza and influenza-like illness in children

Rigamonti V, Torri V, Morris SK, Ieva F, Giaquinto C, Donà D, Di Chiara C, Cantarutti A; CARICE study group

Vaccine. 2025 Apr 19;53:126946. doi: 10.1016/j.vaccine.2025.126946
PMID: 40023131

A population database analysis to describe the residual burden of varicella in Italy-a high vaccination coverage area-from 2004 to 2022

Barbieri E, Cocchio S, Furlan P, Scamarcia A, Cantarutti L, Giaquinto C, Baldo V.

Front Public Health. 2025 Mar 3;13:1412620. doi: 10.3389/fpubh.2025.1412620
PMID: 40098802

Exploring different modelling approaches to forecast the community acute respiratory infections burden in children: an Italian epidemiological time series study

Boracchini R, Canova B, Ferrara P, Barbieri E, Lovaglio PG, Scamarcia A, Corrao G, Donà D, Giaquinto C, Di Chiara C, Cantarutti A.

BMC Public Health. 2025 Feb 28;25(1):810. doi: 10.1186/s12889-025-21984-1. 40022071
PMID: 40022071

A population database analysis to estimate the varicella vaccine effectiveness in children < 14 years in a high vaccination coverage area from 2004 to 2022

Barbieri E, Cocchio S, Furlan P, Scamarcia A, Cantarutti L, Dona’ D, Giaquinto C, Baldo V.
Vaccine. 2024 Dec 2;42(26):126387. doi: 10.1016/j.vaccine.2024.126387. Epub 2024 Sep 26.
PMID: 39332238

Incidence of severe and non-severe SARS-CoV-2 infections in children and adolescents: a population-based cohort study using six healthcare databases from Italy, Spain, and Norway

Durán CE, Riefolo F, Gini R, Barbieri E, Messina D, Garcia P, Martin M, Villalobos F, Stona L, Carreras JJ, Urchueguía A, Correcher-Martínez E, Zhao J, Lupattelli A, Nordeng H, Sturkenboom M.
Eur J Pediatr. 2024 Nov 13;184(1):6. doi: 10.1007/s00431-024-05864-1.
PMID: 39535547

A silent strain: the unseen burden of acute respiratory infections in children

Boracchini R, Canova B, Ferrara P, Cantarutti L, Giaquinto C, Di Chiara C, Cantarutti A.
Ital J Pediatr. 2024 Sep 7;50(1):167. doi: 10.1186/s13052-024-01754-2.
PMID: 39244583

Epidemiological analysis to identify predictors of X-linked hypophosphatemia (XLH) diagnosis in an Italian pediatric population: the EPIX project

Crisafulli S, Ingrasciotta Y, Vitturi G, Fontana A, L’Abbate L, Alessi Y, Ferraù F, Cantarutti L, Lazzerini D, Cannavò S, Trifirò G.
Endocrine. 2024 Aug;85(2):894-905. doi: 10.1007/s12020-024-03793-5. Epub 2024 Apr 9.
PMID: 38592637

Drug utilisation in children and adolescents before and after the start of the COVID-19 pandemic: Interrupted time-series analyses in three European countries

Pedersen E, Tripodi E, Aakjær M, Li H, Cantarutti A, Nyberg F, Andersen M, Lupattelli A, Nordeng H.Paediatr Perinat Epidemiol. 2024 Aug;38(6):450-460. doi: 10.1111/ppe.13046. Epub 2024 Feb 1.
PMID: 38299727

Association Between Early-Life Exposure to Antibiotics and Development of Child Obesity: Population-Based Study in Italy

Cantarutti A, Rescigno P, Da Borso C, Gutierrez de Rubalcava Doblas J, Bressan S, Barbieri E, Giaquinto C, Canova C.
JMIR Public Health Surveill. 2024 May 31;10:e51734. doi: 10.2196/51734.
PMID: 38820573

Monitoring the Epidemiology of Otitis Using Free-Text Pediatric Medical Notes: A Deep Learning Approach

Lanera C, Lorenzoni G, Barbieri E, Piras G, Magge A, Weissenbacher D, Donà D, Cantarutti L, Gonzalez-Hernandez G, Giaquinto C, Gregori D.
J Pers Med. 2023 Dec 25;14(1):28. doi: 10.3390/jpm14010028.
PMID: 38248729

Comparative study showed that children faced a 78% higher risk of new-onset conditions after they had COVID-19

Di Chiara C, Barbieri E, Chen YX, Visonà E, Cavagnis S, Sturniolo G, Parca A, Liberati C, Cantarutti L, Lupattelli A, Le Prevost M, Corrao G, Giaquinto C, Donà D, Cantarutti A.
Acta Paediatr. 2023 Dec;112(12):2563-2571. doi: 10.1111/apa.16966. Epub 2023 Sep 9.
PMID: 37688774

Epidemiology of pediatric psoriasis: a population-based study using two Italian data sources

Lapi F, Cassano N, Barbieri E, Marconi E, Vena GA, Giaquinto C, Cricelli C.
Curr Med Res Opin. 2023 Sep;39(9):1257-1262. doi: 10.1080/03007995.2023.2243216. Epub 2023 Aug 10.
PMID: 37526047 Review.

Assessing the burden of bronchiolitis and lower respiratory tract infections in children ≤24 months of age in Italy, 2012-2019

Barbieri E, Cavagnis S, Scamarcia A, Cantarutti L, Bertizzolo L, Bangert M, Parisi S, Cantarutti A, Baraldi E, Giaquinto C, Baldo V.
Front Pediatr. 2023 May 5;11:1143735. doi: 10.3389/fped.2023.1143735. eCollection 2023.
PMID: 37215598

Retrospective Analysis of the Real-World Use of Topical Antimicrobials in the Paediatric Population with Impetigo in Italy: Focus on the Role of Ozenoxacin 1% Cream

Barbieri E, Cavagnis S, Boracchini R, Scamarcia A, Testa A, Ciarniello MG, Martinelli B, Cantarutti L, Giaquinto C, Cantarutti A. Children (Basel). 2023 Mar 13;10(3):547. doi: 10.3390/children10030547.
PMID: 36980105

The Association Between Pediatric COVID-19 Vaccination and Socioeconomic Position: Nested Case-Control Study From the Pedianet Veneto Cohort

Batzella E, Cantarutti A, Caranci N, Giaquinto C, Barbiellini Amidei C, Canova C. JMIR Public Health Surveill.
2023 Feb 1;9:e44234. doi: 10.2196/44234.
PMID: 36645419

The Economic Burden of Pneumococcal Disease in Children: A Population-Based Investigation in the Veneto Region of Italy

Barbieri E, Porcu G, Petigara T, Senese F, Prandi GM, Scamarcia A, Cantarutti L, Cantarutti A, Giaquinto C.
Children (Basel). 2022 Sep 3;9(9):1347. doi: 10.3390/children9091347.
PMID: 36138656

Early-life exposure to antibiotics and subsequent development of atopic dermatitis

Cantarutti A, Amidei CB, Bonaugurio AS, Rescigno P, Canova C.
Expert Rev Clin Pharmacol. 2022 Jun;15(6):779-785. doi: 10.1080/17512433.2022.2092471. Epub 2022 Jun 21.
PMID: 35723891

A Retrospective Analysis to Estimate the Burden of Invasive Pneumococcal Disease and Non-Invasive Pneumonia in Children <15 Years of Age in the Veneto Region, Italy

Barbieri E, Porcu G, Hu T, Petigara T, Senese F, Prandi GM, Scamarcia A, Cantarutti L, Cantarutti A, Giaquinto C.
Children (Basel). 2022 May 3;9(5):657. doi: 10.3390/children9050657.
PMID: 35626834

Antibiotic Prescription Patterns in the Paediatric Primary Care Setting before and after the COVID-19 Pandemic in Italy: An Analysis Using the AWaRe Metrics

Barbieri E, Liberati C, Cantarutti A, Di Chiara C, Lupattelli A, Sharland M, Giaquinto C, Hsia Y, Doná D.
Antibiotics (Basel). 2022 Mar 29;11(4):457. doi: 10.3390/antibiotics11040457.
PMID: 35453209

A Retrospective Database Analysis to Estimate the Burden of Acute Otitis Media in Children Aged <15 Years in the Veneto Region (Italy)

Barbieri E, Porcu G, Hu T, Petigara T, Senese F, Prandi GM, Scamarcia A, Cantarutti L, Cantarutti A, Giaquinto C.
Children (Basel). 2022 Mar 19;9(3):436. doi: 10.3390/children9030436.
PMID: 35327808

Antibiotic Prescribing Patterns in Paediatric Primary Care in Italy: Findings from 2012-2018

Barbieri E, di Chiara C, Costenaro P, Cantarutti A, Giaquinto C, Hsia Y, Doná D.
Antibiotics (Basel). 2021 Dec 24;11(1):18. doi: 10.3390/antibiotics11010018.
PMID: 35052895

Association of Treated and Untreated Gastroesophageal Reflux Disease in the First Year of Life with the Subsequent Development of Asthma

Cantarutti A, Barbiellini Amidei C, Valsecchi C, Scamarcia A, Corrao G, Gregori D, Giaquinto C, Ludvigsson JF, Canova C.
Int J Environ Res Public Health. 2021 Sep 13;18(18):9633. doi: 10.3390/ijerph18189633.
PMID: 34574556

Impact of bronchiolitis guidelines publication on primary care prescriptions in the Italian pediatric population

Barbieri E, Cantarutti A, Cavagnis S, Cantarutti L, Baraldi E, Giaquinto C, Donà D.
NPJ Prim Care Respir Med. 2021 Mar 19;31(1):15. doi: 10.1038/s41533-021-00228-w.
PMID: 33741991

Antibiotic Prescriptions for Children With Community-acquired Pneumonia: Findings From Italy

Costenaro P, Cantarutti A, Barbieri E, Scamarcia A, Oletto A, Sacerdoti P, Lundin R, Cantarutti L, Giaquinto C, Donà D.
Pediatr Infect Dis J. 2021 Feb 1;40(2):130-136. doi: 10.1097/INF.0000000000002934.
PMID: 33055500

Advance system testing: Vaccine benefit studies using multi-country electronic health data – The example of pertussis vaccination

Tin Tin Htar M, de Ridder M, Braeye T, Correa A, McGee C, de Lusignan S, Duarte-Salles T, Huerta-Alvarez C, Martín-Merino E, Tramontan L, Danieli G, Picelli G, van der Maas N, Berencsi K, Arnheim-Dahlström L, Heininger U, Emborg HD, Weibel D, Bollaerts K, Sturkenboom M.
Vaccine. 2020 Dec 22;38 Suppl 2:B31-B37. doi: 10.1016/j.vaccine.2019.08.078. Epub 2019 Oct 31.
PMID: 31677949

ADVANCE system testing: Can coverage of pertussis vaccination be estimated in European countries using electronic healthcare databases: An example

Emborg HD, Kahlert J, Braeye T, Bauwens J, Bollaerts K, Danieli G, Duarte-Salles T, Glismann S, Huerta-Alvarez C, de Lusignan S, Martín-Merino E, McGee C, Correa A, Tramontan L, Weibel D, Sturkenboom M.
Vaccine. 2020 Dec 22;38 Suppl 2:B22-B30. doi: 10.1016/j.vaccine.2019.07.039. Epub 2019 Oct 31.
PMID: 31677953

ADVANCE database characterisation and fit for purpose assessment for multi-country studies on the coverage, benefits and risks of pertussis vaccinations

Sturkenboom M, Braeye T, van der Aa L, Danieli G, Dodd C, Duarte-Salles T, Emborg HD, Gheorghe M, Kahlert J, Gini R, Huerta-Alvarez C, Martín-Merino E, McGee C, de Lusignan S, Picelli G, Roberto G, Tramontan L, Villa M, Weibel D, Titievsky L.
Vaccine. 2020 Dec 22;38 Suppl 2:B8-B21. doi: 10.1016/j.vaccine.2020.01.100. Epub 2020 Feb 12.
PMID: 32061385

ADVANCE system testing: Estimating the incidence of adverse events following pertussis vaccination in healthcare databases with incomplete exposure data

Dodd C, de Ridder M, Weibel D, Mahaux O, Haguinet F, de Smedt T, de Lusignan S, McGee C, Duarte-Salles T, Emborg HD, Huerta-Alvarez C, Martín-Merino E, Picelli G, Berencsi K, Danieli G, Sturkenboom M.
Vaccine. 2020 Dec 22;38 Suppl 2:B47-B55. doi: 10.1016/j.vaccine.2020.03.050. Epub 2020 Apr 9.
PMID: 32280043

Incidence, risk factors and re-exacerbation rate of severe asthma exacerbations in a multinational, multidatabase pediatric cohort study

Engelkes M, Baan EJ, de Ridder MAJ, Svensson E, Prieto-Alhambra D, Lapi F, Giaquinto C, Picelli G, Boudiaf N, Albers F, Evitt LA, Cockle S, Bradford E, Van Dyke MK, Suruki R, Rijnbeek P, Sturkenboom MCJM, Janssens HM, Verhamme KMC.
Pediatr Allergy Immunol. 2020 Jul;31(5):496-505. doi: 10.1111/pai.13237. Epub 2020 Mar 20.
PMID: 32115766

Multinational cohort study of mortality in patients with asthma and severe asthma

Engelkes M, de Ridder MA, Svensson E, Berencsi K, Prieto-Alhambra D, Lapi F, Giaquinto C, Picelli G, Boudiaf N, Albers FC, Cockle SM, Bradford ES, Suruki RY, Brusselle GG, Rijnbeek PR, Sturkenboom MC, Verhamme KM.
Respir Med. 2020 Apr-May;165:105919. doi: 10.1016/j.rmed.2020.105919. Epub 2020 Mar 2.
PMID: 32174450

Age-specific vaccination coverage estimates for influenza, human papillomavirus and measles containing vaccines from seven population-based healthcare databases from four EU countries – The ADVANCE project

Braeye T, Emborg HD, Llorente-García A, Huerta C, Martín-Merino E, Duarte-Salles T, Danieli G, Tramontan L, Weibel D, McGee C, Villa M, Gini R, Lehtinen M, Titievsky L, Sturkenboom M.
Vaccine. 2020 Apr 3;38(16):3243-3254. doi: 10.1016/j.vaccine.2020.02.082. Epub 2020 Mar 12.
PMID: 32171573

Antibiotic prescriptions in acute otitis media and pharyngitis in Italian pediatric outpatients

Barbieri E, Donà D, Cantarutti A, Lundin R, Scamarcia A, Corrao G, Cantarutti L, Giaquinto C.
Ital J Pediatr. 2019 Aug 17;45(1):103. doi: 10.1186/s13052-019-0696-9.
PMID: 31420054

Impact of a vaccination programme in children vaccinated with ProQuad, and ProQuad-specific effectiveness against varicella in the Veneto region of Italy

Giaquinto C, Gabutti G, Baldo V, Villa M, Tramontan L, Raccanello N, Russo F, Poma C, Scamarcia A, Cantarutti L, Lundin R, Perinetti E, Cornen X, Thomas S, Ballandras C, Souverain A, Hartwig S.
BMC Infect Dis. 2018 Mar 5;18(1):103. doi: 10.1186/s12879-018-3017-9.
PMID: 29506477

Antibiotic-Induced Liver Injury in Paediatric Outpatients: A Case-Control Study in Primary Care Databases

Ferrajolo C, Verhamme KM, Trifirò G, ‘t Jong GW, Picelli G, Giaquinto C, Mazzaglia G, Stricker BH, Rossi F, Capuano A, Sturkenboom MC.
Drug Saf. 2017 Apr;40(4):305-315. doi: 10.1007/s40264-016-0493-y.
PMID: 28025733

Antibiotic Use in Children – A Cross-National Analysis of 6 Countries

Youngster I, Avorn J, Belleudi V, Cantarutti A, Díez-Domingo J, Kirchmayer U, Park BJ, Peiró S, Sanfélix-Gimeno G, Schröder H, Schüssel K, Shin JY, Shin SM, Simonsen GS, Blix HS, Tong A, Trifirò G, Ziv-Baran T, Kim SC.
J Pediatr. 2017 Mar;182:239-244.e1. doi: 10.1016/j.jpeds.2016.11.027. Epub 2016 Dec 21.
PMID: 28012694

Using Prescription Patterns in Primary Care to Derive New Quality Indicators for Childhood Community Antibiotic Prescribing. de Bie S, Kaguelidou F, Verhamme KM, De Ridder M, Picelli G, Straus SM, Giaquinto C, Stricker BH, Bielicki J, Sharland M, Sturkenboom MC; ARPEC study

Pediatr Infect Dis J. 2016 Dec;35(12):1317-1323. doi: 10.1097/INF.0000000000001324.
PMID: 27626915

Community-Acquired Rotavirus Gastroenteritis Compared with Adenovirus and Norovirus Gastroenteritis in Italian Children: A Pedianet Study

Donà D, Mozzo E, Scamarcia A, Picelli G, Villa M, Cantarutti L, Giaquinto C.
Int J Pediatr. 2016;2016:5236243. doi: 10.1155/2016/5236243. Epub 2016 Jan 14.
PMID: 26884770

Risk of upper gastrointestinal bleeding from different drug combinations

Masclee GM, Valkhoff VE, Coloma PM, de Ridder M, Romio S, Schuemie MJ, Herings R, Gini R, Mazzaglia G, Picelli G, Scotti L, Pedersen L, Kuipers EJ, van der Lei J, Sturkenboom MC.
Gastroenterology. 2014 Oct;147(4):784-792.e9; quiz e13-4. doi: 10.1053/j.gastro.2014.06.007. Epub 2014 Jun 14.
PMID: 24937265

Incidence and clinical presentation of acute otitis media in children aged <6 years in European medical practices

Liese JG, Silfverdal SA, Giaquinto C, Carmona A, Larcombe JH, Garcia-Sicilia J, Fuat A, Garces-Sanchez M, Basanta ML, Hiraldo EM, Cantarutti L, Kroeniger W, Vollmar J, Holl K, Pirçon JY, Rosenlund MR.
Epidemiol Infect. 2014 Aug;142(8):1778-88. doi: 10.1017/S0950268813002744. Epub 2013 Dec 13.
PMID: 24330917

Idiopathic acute liver injury in paediatric outpatients: incidence and signal detection in two European countries

Ferrajolo C, Verhamme KM, Trifirò G, ‘t Jong GW, Giaquinto C, Picelli G, Oteri A, de Bie S, Valkhoff VE, Schuemie MJ, Mazzaglia G, Cricelli C, Rossi F, Capuano A, Sturkenboom MC.
Drug Saf. 2013 Oct;36(10):1007-16. doi: 10.1007/s40264-013-0045-7.
PMID: 23591830

Burden of acute otitis media in primary care pediatrics in Italy: a secondary data analysis from the Pedianet database

Marchisio P, Cantarutti L, Sturkenboom M, Girotto S, Picelli G, Dona D, Scamarcia A, Villa M, Giaquinto C; Pedianet.
BMC Pediatr. 2012 Nov 29;12:185. doi: 10.1186/1471-2431-12-185.
PMID: 23190626

Asthma prevalence and drug prescription in asthmatic children

Barbato A, Panizzolo C, Biserna L, Cantarutti L, Giaquinto C, Frati F, Marcucci F, Monciotti C, Testi R, di Blasi P, Sturkenboom MC; Pedianet Family Pediatricians Asthma Study Group (F-PASG).
Eur Ann Allergy Clin Immunol. 2003 Feb;35(2):47-51.
PMID: 12674038